Answer to this is ofcourse yes. All geotargeting search engines needs to operate on a different algorithm than the .com ones to identify potential regional links and regional domains. Various factors affect geotargeted rankings.
Domains hosted, backlinks, domain name itself, visitor tracking, trust network in geotargeted domains, topical directories etc.
So if you want to rank for regional domains be prepared to do something different don't use same .com and .regional extension domains for 2 different rankings.